Supratman 2010 Elusidasi Struktur Senywa Organik Pdf

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Menampilkan 1 - 12 of 12 untuk pencarian: 'Supratman, Unang', lama mencari: 0.11s Daftar Grid Visual Sortir Relevance Date Descending Date Ascending Call Number Author Title. Note = karbon (C). Journal of Microbiology Research 2010, 4. 11 Din, L.B. 22 Supratman U. Elusidasi Struktur Senyawa Organik.

BIOACTIVE COMPOUNDS OF RASAMALA (ALTINGIA EXCELSA NORNHA) LEAVES AS C-MYC PROTO ONCOGENE EXPRESSION SUPPRESSOR OF HUMAN TONGUE CANCER CELL IN VITRO

Risyandi Anwar, Arlette Setiawan, Supriatno Supriatno, Unang Supratman

Abstract


Background: Tongue cancer is a common neoplasm found in oral cavity. It is characterized by aggressive cell growth, poor prognosis and being the cause of mortality. Objectives: to discover bioactive compounds of Rasamala leaves which possess an activity to inhibit SP-C1 human tongue cancer cell proliferation by reducing the expression of c-Myc proto oncogene. Methods: This is an experimental laboratory study using SP-C1 human tongue cancer cell. Separation of bioactive compounds from Rasamala leaves ethyl acetate extract was using various chromatography techniques guided by antiproliferative assay. Results: Two compounds were produced consisting of kaempferol (1) and quercetin (2). Compound 1 and 2 were tested to assess antiproliferative activity of kaempferol and quercetin upon SP-C1tongue cancer cell. IC50 values obtained from antiproliferative assay of each compound were 0.72 and 0.70 ug/ml respectively. Data analysis using ANCOVA test attained a significant value of α=0.05 and proceeded for probit analysis. The activity of compound 1 and 2 was tested on c-Myc proto oncogene and it was acquired that compound 1 and 2 can suppress c-myc proto oncogene expression. Conclusion: Rasamala compounds consist of kaempferol (1) and quercetin (2) which possess an activity as tongue cancer cell proliferation inhibitor by reducing c-myc proto oncogene expression.

Keywords


Altingia excelsa, c-myc, tongue cancer cell SP-C1, kaempferol, quercetin.

References


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THE EXTRACTION OF NATURAL DYES FROM JACKFRUIT WOOD WASTE (Artocarpus Heterophyllus Lamk) WITH WATER SOLVENT BY USING THE MICROWAVE METHOD

Selfina Gala, Mahfud Mahfud, Sumarno Sumarno, Lailatul Qadariyah

Abstract

Currently, exploration of natural dyes is increasingly being activated and developed, especially to find natural sources of dyes from different plant species and also to develop natural dyestuff extraction process technology for textile applications. During this natural dye extraction process is done by conventional methods that require a long time and a large amount of solvent. Therefore, it is a necessary alternative to the use of 'green techniques' are economical in its use. In this research, extraction of Jackfruit wood waste with the microwave by studying the extraction time required to produce the optimum yield and comparing with the conventional method (heat-reflux extraction). Both of these methods use water solvent. On the microwave-assisted extraction, the optimum extraction time at 30 minutes with the acquisition yield of 3.14% (microwave power 400 watt, the ratio of material to solvent 0.02 g/mL). whereas extraction with heat-reflux method showed the optimum extraction time of 180 minutes with a yield of 3.50%. Identification of groups of pigments contained in the Jackfruit wood waste is known categories tannins, flavonoids, and quinones. Fourier Transform Infrared Spectroscopy was used to identify the major chemical groups in the extracted dye. Description of the effects of extraction with microwave and conventional, structural damage shown in a solid surface material using by Scanning Electron Microscopy. Further, to test the application on the fabric dyeing.

Keywords

Natural dyes, Jackfruit wood waste, Microwave assisted extraction, Reflux extraction

References

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